One of the major mechanisms of drug-induced liver injury includes mitochondrial
perturbation and dysfunction. This is not a surprise, given that mitochondria are essential …

Nucleoside analogs have been widely used as antiviral, antitumor, and antiparasitic agents
due to their ability to inhibit nucleic acid synthesis. Adenosine, cytidine, guanosine …

The human population is aging, and the need for interventions to slow progression of age-
related diseases (geroprotective interventions) is growing. Repurposing compounds already …

The intersection of aging and HIV/AIDS is a looming 'epidemic within an epidemic.'This
paper reviews how HIV/AIDS and its therapy cause premature aging or contribute …

Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human
immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome …

Background: Patients with HIV exposed to the antiretroviral drug abacavir may have an
increased risk of cardiovascular disease (CVD). There is concern that this association arises …

Abstract Purpose of Review Weight gain and body fat redistribution are common side effects
of many widely used drugs. We summarize recent literature on prevalence data and …

Worldwide, the benefits of combined antiretroviral (ARV) therapy in morbidity and mortality
due to perinatally acquired human immunodeficiency virus infection are beyond question …

Weight gain or body fat redistribution are common side effects of many widely used drugs.
Weight gain amounts varying between a few kg to an increase of 10% or more of initial body …

HIV-associated sensory neuropathy (HIV-SN) remains a common neurological complication
of HIV infection despite the introduction of effective antiretroviral therapies. Exposure to …