Chloroplast genomes: diversity, evolution, and applications in genetic engineering

H Daniell, CS Lin, M Yu, WJ Chang - Genome biology, 2016 - Springer
Chloroplasts play a crucial role in sustaining life on earth. The availability of over 800
sequenced chloroplast genomes from a variety of land plants has enhanced our …

Plant-made vaccine antigens and biopharmaceuticals

H Daniell, ND Singh, H Mason, SJ Streatfield - Trends in plant science, 2009 - cell.com
Plant cells are ideal bioreactors for the production and oral delivery of vaccines and
biopharmaceuticals, eliminating the need for expensive fermentation, purification, cold …

Advances in plant molecular farming

OO Obembe, JO Popoola, S Leelavathi… - Biotechnology advances, 2011 - Elsevier
Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are
engineered to produce recombinant pharmaceutical and industrial proteins in large …

Plants as bioreactors: recent developments and emerging opportunities

AK Sharma, MK Sharma - Biotechnology advances, 2009 - Elsevier
In recent years, the use of plants as bioreactors has emerged as an exciting area of research
and significant advances have created new opportunities. The driving forces behind the …

Plants as bioreactors for the production of vaccine antigens

S Tiwari, PC Verma, PK Singh, R Tuli - Biotechnology advances, 2009 - Elsevier
Plants have been identified as promising expression systems for commercial production of
vaccine antigens. In phase I clinical trials several plant-derived vaccine antigens have been …

Chloroplast‐derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery

A Davoodi‐Semiromi, M Schreiber… - Plant biotechnology …, 2010 - Wiley Online Library
Cholera and malaria are major diseases causing high mortality. The only licensed cholera
vaccine is expensive; immunity is lost in children within 3 years and adults are not fully …

Chloroplast‐derived vaccines against human diseases: achievements, challenges and scopes

AG Lössl, MT Waheed - Plant biotechnology journal, 2011 - Wiley Online Library
Infectious diseases represent a continuously growing menace that has severe impact on
health of the people worldwide, particularly in the developing countries. Therefore, novel …

Progress and hurdles in the development of vaccines against enterotoxigenic Escherichia coli in humans

W Zhang, DA Sack - Expert review of vaccines, 2012 - Taylor & Francis
Diarrhea is the second leading cause of death in children younger than 5 years.
Enterotoxigenic Escherichia coli (ETEC) strains are the most common bacterial cause of …

Vaccination via chloroplast genetics: affordable protein drugs for the prevention and treatment of inherited or infectious human diseases

H Daniell, HT Chan, EK Pasoreck - Annual review of genetics, 2016 - annualreviews.org
Plastid-made biopharmaceuticals treat major metabolic or genetic disorders, including
Alzheimer's, diabetes, hypertension, hemophilia, and retinopathy. Booster vaccines made in …

Disease prevention: an opportunity to expand edible plant-based vaccines?

C Concha, R Cañas, J Macuer, MJ Torres, AA Herrada… - Vaccines, 2017 - mdpi.com
The lethality of infectious diseases has decreased due to the implementation of crucial
sanitary procedures such as vaccination. However, the resurgence of pathogenic diseases …