[HTML][HTML] Antibiotics and the human gut microbiome: dysbioses and accumulation of resistances

MP Francino - Frontiers in microbiology, 2016 - frontiersin.org
The human microbiome is overly exposed to antibiotics, due, not only to their medical use,
but also to their utilization in farm animals and crops. Microbiome composition can be rapidly …

What is a resistance gene? Ranking risk in resistomes

JL Martínez, TM Coque, F Baquero - Nature Reviews Microbiology, 2015 - nature.com
Metagenomic studies have shown that antibiotic resistance genes are ubiquitous in the
environment, which has led to the suggestion that there is a high risk that these genes will …

Antibiotics and the gut microbiota

SR Modi, JJ Collins, DA Relman - The Journal of clinical …, 2014 - Am Soc Clin Investig
Antibiotics have been a cornerstone of innovation in the fields of public health, agriculture,
and medicine. However, recent studies have shed new light on the collateral damage they …

Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes

JR Huddleston - Infection and drug resistance, 2014 - Taylor & Francis
Bacterial infections are becoming increasingly difficult to treat due to widespread antibiotic
resistance among pathogens. This review aims to give an overview of the major horizontal …

The initial state of the human gut microbiome determines its reshaping by antibiotics

F Raymond, AA Ouameur, M Déraspe, N Iqbal… - The ISME …, 2016 - academic.oup.com
Microbiome studies have demonstrated the high inter-individual diversity of the gut
microbiota. However, how the initial composition of the microbiome affects the impact of …

The human gut resistome

W Van Schaik - … Transactions of the Royal Society B …, 2015 - royalsocietypublishing.org
In recent decades, the emergence and spread of antibiotic resistance among bacterial
pathogens has become a major threat to public health. Bacteria can acquire antibiotic …

Antimicrobial activity and resistance: influencing factors

J Li, S Xie, S Ahmed, F Wang, Y Gu, C Zhang… - Frontiers in …, 2017 - frontiersin.org
Rational use of antibiotic is the key approach to improve the antibiotic performance and
tackling of the antimicrobial resistance. The efficacy of antimicrobials are influenced by many …

Addressing the antibiotic resistance problem with probiotics: reducing the risk of its double-edged sword effect

ICVJ Imperial, JA Ibana - Frontiers in microbiology, 2016 - frontiersin.org
Antibiotic resistance is a global public health problem that requires our attention.
Indiscriminate antibiotic use is a major contributor in the introduction of selective pressures …

Metagenomic approaches for understanding new concepts in microbial science

LF Alves, CA Westmann, GL Lovate… - … journal of genomics, 2018 - Wiley Online Library
Over the past thirty years, since the dawn of metagenomic studies, a completely new (micro)
universe was revealed, with the potential to have profound impacts on many aspects of the …

Prediction of the intestinal resistome by a three-dimensional structure-based method

E Ruppé, A Ghozlane, J Tap, N Pons, AS Alvarez… - Nature …, 2019 - nature.com
The intestinal microbiota is considered to be a major reservoir of antibiotic resistance
determinants (ARDs) that could potentially be transferred to bacterial pathogens via mobile …