Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic
multinucleation process not only increases cell size but causes functional alterations …

The foreign body reaction composed of macrophages and foreign body giant cells is the end-
stage response of the inflammatory and wound healing responses following implantation of …

Osteoclasts (OCLs) are hematopoietic cells whose physiological function is to degrade
bone. OCLs are key players in the processes that determine and maintain the mass, shape …

Monocytes and macrophages are innate immune cells with diverse functions ranging from
phagocytosis of microorganisms to forming a bridge with the adaptive immune system. A …

Fusion of macrophages leads to the formation of osteoclasts in bone and of multinucleated
giant cells in granulomas. The precise function of granuloma-associated multinucleates …

Interactions between cells and their surroundings are important for proper function and
homeostasis in a multicellular organism. These interactions can either be established …

Timely removal of dying or pathogenic cells by phagocytes is essential to maintaining host
homeostasis. Phagocytes execute the clearance process with high fidelity while sparing …

Monocyte lineage cells play important roles in health and disease. Their differentiation into
macrophages is crucial for a broad array of immunologic processes that regulate …

CD47 is a ubiquitous 50 kDa five‐spanning membrane receptor that belongs to the
immunoglobulin superfamily. This receptor, also known as integrin‐associated protein …

Cell–cell fusion is a highly regulated and dramatic cellular event that is required for
development and homeostasis. Fusion may also play a role in the development of cancer …