Local and systemic effects of the multifaceted epicardial adipose tissue depot

G Iacobellis - Nature Reviews Endocrinology, 2015 - nature.com
Epicardial adipose tissue is a unique and multifaceted fat depot with local and systemic
effects. This tissue is distinguished from other visceral fat depots by a number of anatomical …

Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Detecting human coronary inflammation by imaging perivascular fat

AS Antonopoulos, F Sanna, N Sabharwal… - Science translational …, 2017 - science.org
Early detection of vascular inflammation would allow deployment of targeted strategies for
the prevention or treatment of multiple disease states. Because vascular inflammation is not …

Perivascular adipose tissue and coronary atherosclerosis: from biology to imaging phenotyping

A Lin, D Dey, DTL Wong, N Nerlekar - Current atherosclerosis reports, 2019 - Springer
Abstract Purpose of Review Perivascular adipose tissue (PVAT) has a complex, bidirectional
relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory …

Pericoronary adipose tissue computed tomography attenuation distinguishes different stages of coronary artery disease: a cross-sectional study

A Lin, N Nerlekar, J Yuvaraj… - European Heart …, 2021 - academic.oup.com
Aims Vascular inflammation inhibits local adipogenesis in pericoronary adipose tissue
(PCAT) and this can be detected on coronary computed tomography angiography (CCTA) …

[HTML][HTML] 'Browning'the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk

P Aldiss, G Davies, R Woods, H Budge… - International journal of …, 2017 - Elsevier
Excess visceral adiposity, in particular that located adjacent to the heart and coronary
arteries is associated with increased cardiovascular risk. In the pathophysiological state …

[PDF][PDF] Clinical importance of epicardial adipose tissue

E Nagy, AL Jermendy, B Merkely… - Archives of Medical …, 2017 - termedia.pl
Different visceral fat compartments have several systemic effects and may play a role in the
development of both insulin resistance and cardiovascular diseases. In the last couple of …

The pathobiology of perivascular adipose tissue (PVAT), the fourth layer of the blood vessel wall

C Hillock-Watling, AI Gotlieb - Cardiovascular Pathology, 2022 - Elsevier
The perivascular adipose tissue (PVAT) is an adipose tissue depot which surrounds most
human blood vessels. It is metabolically active and has both a protective and a pathogenic …

The relationship between enhancing left atrial adipose tissue at CT and recurrent atrial fibrillation

AT Huber, S Fankhauser, L Chollet, S Wittmer, A Lam… - Radiology, 2022 - pubs.rsna.org
Background The association of epicardial adipose tissue (EAT) and its metabolic activity
with atrial fibrillation (AF) is an area of active investigation. Left atrial (LA) enhancing EAT (e …

Potential role of perivascular adipose tissue in modulating atherosclerosis

S Ahmadieh, HW Kim, NL Weintraub - Clinical Science, 2020 - portlandpress.com
Perivascular adipose tissue (PVAT) directly juxtaposes the vascular adventitia and contains
a distinct mixture of mature adipocytes, preadipocytes, stem cells, and inflammatory cells …