Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential

N Song, M Scholtemeijer, K Shah - Trends in pharmacological sciences, 2020 - cell.com
Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most
promising means of allogeneic cell therapy. MSCs have inherent immunomodulatory …

[HTML][HTML] Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

X Jiang, J Wang, X Deng, F Xiong, J Ge, B Xiang, X Wu… - Molecular cancer, 2019 - Springer
Tumor immune escape is an important strategy of tumor survival. There are many
mechanisms of tumor immune escape, including immunosuppression, which has become a …

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

TL Song, ML Nairismägi, Y Laurensia… - Blood, The Journal …, 2018 - ashpublications.org
Mature T-cell lymphomas, including peripheral T-cell lymphoma (PTCL) and extranodal
NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas …

[HTML][HTML] Soluble PD-1: predictive, prognostic, and therapeutic value for cancer immunotherapy

M Khan, Z Zhao, S Arooj, Y Fu, G Liao - Frontiers in immunology, 2020 - frontiersin.org
Programmed death protein 1 (PD-1) interaction with PD-L1 deliver immunosuppressive
environment for tumor growth, and its blockade with directed monoclonal antibodies (anti …

[HTML][HTML] Immunomodulatory mechanisms and therapeutic potential of mesenchymal stem cells

G Yang, X Fan, Y Liu, P Jie, M Mazhar, Y Liu… - Stem Cell Reviews and …, 2023 - Springer
Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell
therapy, owing to their multipotent nature and ability to display potent and varied functions in …

[HTML][HTML] Much more than IL-17A: cytokines of the IL-17 family between microbiota and cancer

A Brevi, LL Cogrossi, G Grazia… - Frontiers in …, 2020 - frontiersin.org
The interleukin-(IL-) 17 family of cytokines is composed of six members named IL-17A, IL-
17B, IL-17C, IL-17D, IL-17E, and IL-17F. IL-17A is the prototype of this family, and it was the …

Quercetin-ferrum nanoparticles enhance photothermal therapy by modulating the tumor immunosuppressive microenvironment

L Li, M Zhang, T Liu, J Li, S Sun, J Chen, Z Liu… - Acta Biomaterialia, 2022 - Elsevier
Photothermal therapy (PTT) was reported to induce synergistic immunogenic cell death
(ICD) which may convert tumor cells into “therapeutic vaccines”. However, this is often …

The JAK/STAT3 axis: A comprehensive drug target for solid malignancies

J Huynh, N Etemadi, F Hollande, M Ernst… - Seminars in cancer …, 2017 - Elsevier
Intercellular communication between tumor cells, immune cells and the stroma characterises
the tumor microenvironment, which is instrumental for establishing the ecological niche that …

Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells

V Sasidharan Nair, SM Toor, BR Ali… - Expert opinion on …, 2018 - Taylor & Francis
Objectives: Breast cancer is the most commonly diagnosed cancer, and it is a leading cause
of cancer-related deaths in females worldwide. Triple-negative breast cancer (TNBC) …

Signal transducer and activator of transcription 3 signaling in tumor immune evasion

L Zhang, K Kuca, L You, Y Zhao, K Musilek… - Pharmacology & …, 2022 - Elsevier
The underlying mechanism of tumor immune evasion is a highly concerning subject for
researchers. Increasing evidences reveal that the over-activated signal transducer and …