Polymyxin and lipopeptide antibiotics: membrane-targeting drugs of last resort

EVK Ledger, A Sabnis, AM Edwards - Microbiology, 2022 - microbiologyresearch.org
The polymyxin and lipopeptide classes of antibiotics are membrane-targeting drugs of last
resort used to treat infections caused by multi-drug-resistant pathogens. Despite similar …

Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces

S Zhang, Y Chen, J Zhu, Q Lu, MJ Cryle… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

Natural products acting against S. aureus through membrane and cell wall disruption

G Kumar, K Engle - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several
community and hospital-acquired infections with life-threatening complications such as …

Bacterial cell membranes and their role in daptomycin resistance: A review

AH Nguyen, KS Hood, E Mileykovskaya… - Frontiers in Molecular …, 2022 - frontiersin.org
Lipids play a major role in bacterial cells. Foremost, lipids are the primary constituents of the
cell membrane bilayer, providing structure and separating the cell from the surrounding …

A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens

NP Buijs, HC Vlaming, I Kotsogianni, M Arts… - Proceedings of the …, 2024 - pnas.org
Bacitracin is a macrocyclic peptide antibiotic that is widely used as a topical treatment for
infections caused by gram-positive bacteria. Mechanistically, bacitracin targets bacteria by …

Identification of DraRS in Clostridioides difficile, a two-component regulatory system that responds to lipid II-interacting antibiotics

AG Pannullo, BR Zbylicki, CD Ellermeier - Journal of bacteriology, 2023 - Am Soc Microbiol
Clostridioides difficile is a Gram-positive opportunistic pathogen that results in 220,000
infections, 12,000 deaths, and upwards of $1 billion in medical costs in the United States …

Time-resolved atomistic imaging and statistical analysis of daptomycin oligomers with and without calcium ions

T Nakamuro, K Kamei, K Sun, JW Bode… - Journal of the …, 2022 - ACS Publications
Daptomycin (DP) is effective against multiple drug-resistant Gram-positive pathogens
because of its distinct mechanism of action. An accepted mechanism includes Ca2+ …

The effects of daptomycin on cell wall biosynthesis in Enterococcal faecalis

B Rimal, J Chang, C Liu, R Rashid, M Singh, SJ Kim - Scientific Reports, 2023 - nature.com
Daptomycin is a cyclic lipodepsipeptide antibiotic reserved for the treatment of serious
infections by multidrug-resistant Gram-positive pathogens. Its mode of action is considered …

The Chiral Target of Daptomycin Is the 2R,2′S Stereoisomer of Phosphatidylglycerol

R Moreira, SD Taylor - Angewandte Chemie, 2022 - Wiley Online Library
Daptomycin (dap) is an important antibiotic that interacts with the bacterial membrane lipid
phosphatidylglycerol (PG) in a calcium‐dependent manner. The enantiomer of dap (ent …

Daptomycin avoids drug resistance mediated by the BceAB transporter in Streptococcus pneumoniae

A Faure, S Manuse, M Gonin, C Grangeasse… - Microbiology …, 2024 - Am Soc Microbiol
Drug-resistant bacteria are a serious threat to human health as antibiotics are gradually
losing their clinical efficacy. Comprehending the mechanism of action of antimicrobials and …