The aim of this critical review is to provide a broad but digestible overview of
mechanochemical synthesis, ie reactions conducted by grinding solid reactants together …

This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

Cocrystals, a long known but understudied class of crystalline solids, have attracted interest
from crystal engineers and pharmaceutical scientists in the past decade and are now an …

Recently, the application of mechanochemical strategies in organic synthesis has attracted
the attention of both the academic and industrial chemical communities. The high efficiency …

Mechanochemical reactions effected by milling or grinding are an attractive means to
conduct chemical reactions dependent on molecular recognition and to systematically …

The preparation of co-crystals via mechanochemistry combines the quest for clean and
green processes with the investigation of multicomponent new materials, among the …

The increasing prevalence of poorly soluble drugs in development provides notable risk of
new products demonstrating low and erratic bioavailabilty with consequences for safety and …

A brief and systematic overview of recent advances in understanding the mechanism of
mechanochemical cocrystallization at macroscopic (bulk phase transformations) and …

Active pharmaceutical ingredients (APIs) are most commonly formulated and delivered to
patients in the solid state. Recently, an alternative API solid-state form, namely the …

A detailed description of polymorph screening procedures is presented. On the basis of the
results of 245 polymorph screens, organic compounds were found to exist in multiple solid …