Objectives Microbiological diagnosis is essential during clinical management of focal
infections. Metagenomic next generation sequencing (mNGS) has been reported as a …

Background Pathogens identification is critical for the proper diagnosis and precise
treatment of infective endocarditis (IE). Although blood and valve cultures are the gold …

We read with interest a recent article in this journal that the predominant pathogen shift to
CV-A6 might contribute to the abnormal growth of Hand, foot, and mouth disease (HFMD) …

Background Microorganism identification is critical for the early diagnosis and management
of infectious endophthalmitis, but traditional culture can yield false‐negative results …

Purpose Intra-abdominal infections (IAI) are gradually becoming common in the emergency
department, though the incidence is low and the prognosis is fair, as the symptoms are …

Motivation The recently developed barcoding-based synthetic long read (SLR) technologies
have already found many applications in genome assembly and analysis. However …

A comment on this article appears in" Failure of metagenomics in detecting emerging
pathogens, the Clostridium difficile paradigm." J Infect. 2019 May; 78 (5): 409-421. A …

Human papillomavirus (HPV) is a major pathogen that causes cervical cancer and many
other related diseases. HPV infection related cervical microbiome could be an induce factor …

Rapid and accurate etiologic diagnosis accelerates targeted antimicrobial therapy.
Metagenomic analysis has played a critical role in pathogen identification. In this study, we …

In this study, we applied metagenomic next-generation sequencing (mNGS) to detect the
causative pathogens in brain abscess samples from 4 pediatric patients. NGS could offer …