Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases that were first
discovered as proteases, which target and cleave extracellular proteins. During the past 20 …

As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …

Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. Most
cardiovascular deaths are caused by ischaemic heart diseases such as myocardial …

Impaired function of the endoplasmic reticulum (ER) is followed by evolutionarily conserved
cell stress responses, which are employed by cells, including cardiomyocytes, to maintain …

In both excitable and nonexcitable cells, diverse physiological processes are linked to
different calcium microdomains within nanoscale junctions that form between the plasma …

Ischemic heart disease remains a leading cause of human mortality worldwide. One form of
ischemic heart disease is ischemia–reperfusion injury caused by the reintroduction of blood …

BACKGROUND: Cardiac fibroblast activation contributes to adverse remodeling, fibrosis,
and dysfunction in the pressure-overloaded heart. Although early fibroblast TGF-β …

Coronary heart disease (CHD) is a prevalent cardiac disease that causes over 370,000
deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the …

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. Patients with HF
exhibit a loss of junctophilin-2 (JPH2), a structural protein critical in forming junctional …