Organic cation transporters in health and disease
H Koepsell, LC Daws - Pharmacological reviews, 2020 - Elsevier
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
Thiamin function, metabolism, uptake, and transport
Vitamins are crucial components in the diet of animals and many other living organisms.
One of these essential nutrients, thiamin, is known to be involved in several cell functions …
One of these essential nutrients, thiamin, is known to be involved in several cell functions …
Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications
H Koepsell, K Lips, C Volk - Pharmaceutical research, 2007 - Springer
The body is equipped with broad-specificity transporters for the excretion and distribution of
endogeneous organic cations and for the uptake, elimination and distribution of cationic …
endogeneous organic cations and for the uptake, elimination and distribution of cationic …
Organic cation transporters
H Koepsell, BM Schmitt, V Gorboulev - Reviews of physiology …, 2003 - Springer
Over the last 15 years, a number of transporters that translocate organic cations were
characterized functionally and also identified on the molecular level. Organic cations include …
characterized functionally and also identified on the molecular level. Organic cations include …
Polyspecific organic cation transporters: their functions and interactions with drugs
H Koepsell - Trends in pharmacological sciences, 2004 - cell.com
The body is equipped with broad-specificity transporters for the uptake, elimination and
distribution of drugs, environmental toxins and metabolic waste products. The organic cation …
distribution of drugs, environmental toxins and metabolic waste products. The organic cation …
Drug uptake systems in liver and kidney
JE van Montfoort, B Hagenbuch… - Current drug …, 2003 - ingentaconnect.com
The hepatobiliary system and the kidneys are the main routes by which drugs and their
metabolites leave the body. Compounds that are mainly excreted into bile in general have …
metabolites leave the body. Compounds that are mainly excreted into bile in general have …
Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation
Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …
Organic cation transporters
G Ciarimboli - Xenobiotica, 2008 - Taylor & Francis
1. Organic cation transporters (OCTs) translocate endogenous (eg dopamine) and
exogenous (eg drugs) substances of cationic nature and, therefore, play an important role in …
exogenous (eg drugs) substances of cationic nature and, therefore, play an important role in …
Regulation of organic cation transport
G Ciarimboli, E Schlatter - Pflügers Archiv, 2005 - Springer
Transport of organic cations (OC) is important for the recycling of endogenous OC and also
a necessary step for detoxification of exogenous OC in the body. Even though the …
a necessary step for detoxification of exogenous OC in the body. Even though the …
Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology
Changes in the uptake of many drugs by the target cells may dramatically affect the
pharmacological response. Thus, downregulation of SLC22A1, which encodes the organic …
pharmacological response. Thus, downregulation of SLC22A1, which encodes the organic …