Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Melanoma is the most aggressive and dangerous form of skin cancer that develops from
transformed melanocytes. It is crucial to identify melanoma at its early stages, in situ, as it is …

Hotspot mutations in splicing factor genes have been recently reported at high frequency in
hematological malignancies, suggesting the importance of RNA splicing in cancer. We …

Melanoma is characterised by its ability to metastasise at early stages of tumour
development. Current clinico‐pathologic staging based on the American Joint Committee on …

Abstract Knowledge of key drivers and therapeutic targets in mucosal melanoma is limited
due to the paucity of comprehensive mutation data on this rare tumor type. To better …

Mucosal melanoma is a rare and aggressive subtype of melanoma that has a less favorable
prognosis due to the lack of understanding and identification of oncogenic drivers. Recently …

Melanoma is a cancer of melanocytes, with multiple subtypes based on body site location.
Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal …

Despite recent genetic advances and numerous ongoing therapeutic trials, malignant
melanoma remains fatal, and prognostic factors as well as more efficient treatments are …

Major advances in our understanding of cancer pathogenesis and therapy have come from
efforts to catalog genomic alterations in cancer. A growing number of large-scale genomic …

SF3B1 is the most frequently mutated spliceosomal gene in cancer. Several hotspot
mutations are known to disrupt the interaction of SF3B1 with another splicing factor, SUGP1 …