X-ray phase-contrast imaging: from pre-clinical applications towards clinics

A Bravin, P Coan, P Suortti - Physics in Medicine & Biology, 2012 - iopscience.iop.org
Phase-contrast x-ray imaging (PCI) is an innovative method that is sensitive to the refraction
of the x-rays in matter. PCI is particularly adapted to visualize weakly absorbing details like …

Gene therapy for cystic fibrosis lung disease: overcoming the barriers to translation to the clinic

M Donnelley, DW Parsons - Frontiers in pharmacology, 2018 - frontiersin.org
Cystic fibrosis (CF) is a progressive, chronic and debilitating genetic disease caused by
mutations in the CF Transmembrane-Conductance Regulator (CFTR) gene. Unrelenting …

Improved In vivo Assessment of Pulmonary Fibrosis in Mice using X-Ray Dark-Field Radiography

A Yaroshenko, K Hellbach, AÖ Yildirim, TM Conlon… - Scientific reports, 2015 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with a median
life expectancy of 4–5 years after initial diagnosis. Early diagnosis and accurate monitoring …

Quantitative single-exposure x-ray phase contrast imaging using a single attenuation grid

KS Morgan, DM Paganin, KKW Siu - Optics express, 2011 - opg.optica.org
A single-exposure quantitative method of x-ray phase contrast imaging, suitable for animal
in vivo observations, is described and shown experimentally both for a known static sample …

Lung function imaging methods in cystic fibrosis pulmonary disease

M Kołodziej, MJ de Veer, M Cholewa, GF Egan… - Respiratory …, 2017 - Springer
Monitoring of pulmonary physiology is fundamental to the clinical management of patients
with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung …

[PDF][PDF] Methods for dynamic synchrotron X-ray respiratory imaging in live animals

KS Morgan, D Parsons, P Cmielewski… - Journal of …, 2020 - journals.iucr.org
Small-animal physiology studies are typically complicated, but the level of complexity is
greatly increased when performing live-animal X-ray imaging studies at synchrotron and …

Single‐dose lentiviral gene transfer for lifetime airway gene expression

AG Stocker, KL Kremer, R Koldej… - The Journal of Gene …, 2009 - Wiley Online Library
Background Cystic fibrosis (CF) is caused by a defect in cystic fibrosis transmembrane
conductance regulator (CFTR) activity, often resulting in an incurable airway disease. Gene …

[PDF][PDF] Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung

S Mohammadi, E Larsson, F Alves… - Journal of …, 2014 - journals.iucr.org
Propagation-based X-ray phase-contrast computed tomography (PBI) has already proven its
potential in a great variety of soft-tissue-related applications including lung imaging …

Pseudomonas aeruginosa triggers CFTR-mediated airway surface liquid secretion in swine trachea

X Luan, VA Campanucci, M Nair… - Proceedings of the …, 2014 - National Acad Sciences
Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in the
gene encoding for the anion channel cystic fibrosis transmembrane conductance regulator …

The projection approximation and edge contrast for x-ray propagation-based phase contrast imaging of a cylindrical edge

KS Morgan, KKW Siu, DM Paganin - Optics Express, 2010 - opg.optica.org
We examine the projection approximation in the context of propagation-based phase
contrast imaging using hard x-rays. Specifically, we consider the case of a cylinder or a …