A blood-based marker of mitochondrial DNA damage in Parkinson's disease

R Qi, E Sammler, CP Gonzalez-Hunt… - Science translational …, 2023 - science.org
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and
neuroprotective or disease-modifying interventions remain elusive. High-throughput markers …

Migraine heritability and beyond: A scoping review of twin studies

IA Olofsson - Headache: The Journal of Head and Face Pain, 2024 - Wiley Online Library
Objective This scoping review aimed to summarize current knowledge from twin studies on
migraine. Migraine heritability, genetic correlations with migraine comorbid disorders, and …

Discrimination of monozygotic twins using mtDNA heteroplasmy through probe capture enrichment and massively parallel sequencing

Y Zhong, K Zeng, A Adnan, YZ Li, X Hou, Y Pan… - International Journal of …, 2023 - Springer
Differentiating between monozygotic (MZ) twins remains difficult because they have the
same genetic makeup. Applying the traditional STR genotyping approach cannot …

Individual genetic heterogeneity

M Vihinen - Genes, 2022 - mdpi.com
Genetic variation has been widely covered in literature, however, not from the perspective of
an individual in any species. Here, a synthesis of genetic concepts and variations relevant …

Promotion effect of FGF23 on osteopenia in congenital scoliosis through FGFr3/TNAP/OPN pathway

H Zhang, G Xiang, J Li, S He, Y Wang… - Chinese Medical …, 2023 - journals.lww.com
Background: Congenital scoliosis (CS) is a complex spinal malformation of unknown
etiology with abnormal bone metabolism. Fibroblast growth factor 23 (FGF23), secreted by …

Transcriptome profiling reveals differential expression of circadian behavior genes in peripheral blood of monozygotic twins discordant for Parkinson's disease

EI Semenova, IN Vlasov, SA Partevian, AV Rosinskaya… - Cells, 2022 - mdpi.com
Parkinson's disease (PD) is one of the most common neurodegenerative diseases.
Investigating individuals with the most identical genetic background is optimal for minimizing …

Cytokine Profiling in Human iPSC-Derived Dopaminergic Neuronal and Microglial Cultures

E Knappe, F Rudolph, C Klein, P Seibler - Cells, 2023 - mdpi.com
Aside from the degeneration of dopaminergic neurons, inflammation is a key component in
the movement disorder Parkinson's disease (PD). Microglia activation as well as elevated …

[HTML][HTML] Endoplasmic Reticulum Proteins Impact Penetrance in a Pink1-Mutant Drosophila Model

M Vos, F Ott, H Gillo, G Cesare, S Misera… - International Journal of …, 2025 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder with a high variability of age at
onset, disease severity, and progression. This suggests that other factors, including genetic …

Transcriptome analysis of induced pluripotent stem cells and neuronal progenitor cells, derived from discordant monozygotic twins with Parkinson's disease

IN Vlasov, AK Alieva, EV Novosadova, EL Arsenyeva… - Cells, 2021 - mdpi.com
Parkinson's Disease (PD) is a widespread severe neurodegenerative disease that is
characterized by pronounced deficiency of the dopaminergic system and disruption of the …

A mitochondrial blood-based patient stratification candidate biomarker for Parkinson's disease

R Qi, E Sammler, CP Gonzalez-Hunt, N Pena… - bioRxiv, 2022 - biorxiv.org
Parkinson's disease (PD) is the most common neurodegenerative movement disorder and
neuroprotective interventions remain elusive. High throughput biomarkers aimed to stratify …