A theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces

RK Sadhu, SR Barger, S Penič, A Iglič, M Krendel… - Soft Matter, 2023 - pubs.rsc.org
Phagocytosis is the process of engulfment and internalization of comparatively large
particles by cells, and plays a central role in the functioning of our immune system. We study …

Apicomplexan F‐actin is required for efficient nuclear entry during host cell invasion

M Del Rosario, J Periz, G Pavlou, O Lyth… - EMBO …, 2019 - embopress.org
The obligate intracellular parasites Toxoplasma gondii and Plasmodium spp. invade host
cells by injecting a protein complex into the membrane of the targeted cell that bridges the …

Effect of relative timescale on a system of particles sliding on a fluctuating energy landscape: Exact derivation of product measure condition

C Khamrai, S Chatterjee - Physical Review E, 2024 - APS
We consider a system of hardcore particles advected by a fluctuating potential energy
landscape, whose dynamics is in turn affected by the particles. Earlier studies have shown …

Actin filaments growing against an elastic membrane: Effect of membrane tension

RK Sadhu, S Chatterjee - Physical Review E, 2018 - APS
We study the force generation by a set of parallel actin filaments growing against an elastic
membrane. The elastic membrane tries to stay flat and any deformation from this flat state …

Polymerisation force of a rigid filament bundle: diffusive interaction leads to sublinear force-number scaling

J Valiyakath, M Gopalakrishnan - Scientific Reports, 2018 - nature.com
Polymerising filaments generate force against an obstacle, as in, eg, microtubule-
kinetochore interactions in the eukaryotic cell. Earlier studies of this problem have not …

Undulation of a moving fluid membrane pushed by filament growth

H Noguchi, O Pierre-Louis - Scientific Reports, 2021 - nature.com
Biomembranes experience out-of-equilibrium conditions in living cells. Their undulation
spectra are different from those in thermal equilibrium. Here, we report on the undulation of a …

Interplay between surface and bending energy helps membrane protrusion formation

RK Sadhu, S Chatterjee - Physical Review E, 2019 - APS
We consider a one-dimensional elastic membrane, which is pushed by growing filaments.
The filaments tend to grow by creating local protrusions in the membrane and this process …

Influence of cross-linking and retrograde flow on formation and dynamics of lamellipodium

A Atakhani, F Mohammad-Rafiee, A Gholami - PloS one, 2019 - journals.plos.org
The forces that arise from the actin cortex play a crucial role in determining the membrane
deformation. These include protrusive forces due to actin polymerization, pulling forces due …

Energy-based Modelling of Single Actin Filament Polymerisation Using Bond Graphs

PJ Gawthrop, M Pan, V Rajagopal - bioRxiv, 2024 - biorxiv.org
Bond graphs provide an energy-based methodology for modelling complex systems in a
hierarchical fashion; at the moment, the method allows biological system with both chemical …

Actin filaments pushing against a barrier: Comparison between two force generation mechanisms

RK Sadhu, S Chatterjee - The European Physical Journal E, 2019 - Springer
To theoretically understand force generation properties of actin filaments, many models
consider growing filaments pushing against a movable obstacle or barrier. In order to grow …