People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …

Increasing evidence coming from both experimental and humans' studies strongly suggest
the existence of a link between epilepsy, in particular temporal lobe epilepsy (TLE), and …

Alzheimer's disease is pathologically characterized by abnormal accumulation of amyloid-
beta plaques, neurofibrillary tangles, oxidative stress, neuroinflammation, and …

Abstract Parvalbumin-positive (PV+) basket neurons are fast-spiking, non-adapting
inhibitory interneurons whose oscillatory activity is essential for regulating cortical …

Both Fyn and tau have been associated with neuronal hyperexcitability and neurotoxicity in
many tauopathies, including Alzheimer's disease (AD). Individual genetic ablation of fyn or …

Introduction: Tau is a microtubule associated phosphoprotein found principally in neurons.
Prevailing dogma continues to define microtubule stabilization as the major function of tau in …

Epilepsy and Alzheimer's disease share some common pathologies such as
neurodegeneration, seizures and impaired cognition. However, the molecular mechanisms …

Emerging findings point toward an important interconnection between epilepsy and
Alzheimer's disease (AD) pathogenesis. Patients with epilepsy (PWE) commonly exhibit …

Background Glutamate is one of the most important excitatory neurotransmitters in the
mammalian brain and is involved in a variety of neurological disorders. Increasing evidence …

Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6. Cg-
Mapttm1 (EGFP) Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn …