Humans rely increasingly on sensors to address grand challenges and to improve quality of
life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are …

Whole blood, as one of the most significant biological fluids, provides critical information for
health management and disease monitoring. Over the past 10 years, advances in …

Aptamers are being applied as affinity reagents in analytical applications owing to their high
stability, compact size and amenability to chemical modification. Generating aptamers with …

The ability to track the levels of specific molecules, such as drugs, metabolites, and
biomarkers, in the living body, in real time and for long durations, would improve our …

Body-based biomolecular sensing systems, including wearable, implantable and
consumable sensors allow comprehensive health-related monitoring. Glucose sensors have …

Biomarkers are crucial biological indicators in medical diagnostics and therapy. However,
the process of biomarker discovery and validation is hindered by a lack of standardized …

We present a generalizable approach for designing biosensors that can continuously detect
small-molecule biomarkers in real time and without sample preparation. This is achieved by …

The focus on precise medicine enhances the need for timely diagnosis and frequent
monitoring of chronic diseases. Moreover, the recent pandemic of severe acute respiratory …

Covalent organic frameworks (COFs) with unique structural merits show substantial potential
in the construction of biosensors. However, high‐performance COF‐based biosensors have …

Nucleic acids are remarkable molecules. In addition to Watson–Crick base pairing, the
different structural motifs of these molecules can bind non‐nucleic acid targets or catalyze …