The quest to slow ageing through drug discovery

L Partridge, M Fuentealba, BK Kennedy - Nature Reviews Drug …, 2020 - nature.com
Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Roles of telomere biology in cell senescence, replicative and chronological ageing

J Liu, L Wang, Z Wang, JP Liu - Cells, 2019 - mdpi.com
Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin
structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard …

Anti-senescent drug screening by deep learning-based morphology senescence scoring

D Kusumoto, T Seki, H Sawada, A Kunitomi… - Nature …, 2021 - nature.com
Advances in deep learning technology have enabled complex task solutions. The accuracy
of image classification tasks has improved owing to the establishment of convolutional …

Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

R Yu, X Cao, L Sun, J Zhu, BM Wasko, W Liu… - Nature …, 2021 - nature.com
Histone acetylations are important epigenetic markers for transcriptional activation in
response to metabolic changes and various stresses. Using the high-throughput …

The potential of calorie restriction and calorie restriction mimetics in delaying aging: Focus on experimental models

E Giacomello, L Toniolo - Nutrients, 2021 - mdpi.com
Aging is a biological process determined by multiple cellular mechanisms, such as genomic
instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient …

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4 …

DE Harrison, R Strong, P Reifsnyder, N Rosenthal… - Geroscience, 2024 - Springer
In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1× C3D2F1 cross,
the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12%(p= 0.003 …

Age-dependent decline in stress response capacity revealed by proteins dynamics analysis

K Chen, W Shen, Z Zhang, F Xiong, Q Ouyang… - Scientific reports, 2020 - nature.com
The aging process is regarded as the progressive loss of physiological integrity, leading to
impaired biological functions and the increased vulnerability to death. Among various …

A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels

G Urbonaite, JTH Lee, P Liu, GE Parada… - Communications …, 2021 - nature.com
Stochastic gene expression leads to inherent variability in expression outcomes even in
isogenic single-celled organisms grown in the same environment. The Drop-Seq technology …

Replicative aging in pathogenic fungi

S Bhattacharya, T Bouklas, BC Fries - Journal of Fungi, 2020 - mdpi.com
Candida albicans, Candida auris, Candida glabrata, and Cryptococcus neoformans are
pathogenic yeasts which can cause systemic infections in immune-compromised as well as …

The systems biology of single-cell aging

R Song, EA Sarnoski, M Acar - Iscience, 2018 - cell.com
Aging is a leading cause of human morbidity and mortality, but efforts to slow or reverse its
effects are hampered by an incomplete understanding of its multi-faceted origins. Systems …