The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis
mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of …

Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. It shows a
wide spectrum of morphological presentations and the diagnosis could be challenging due …

CDX2 is a recently cloned homeobox gene that encodes an intestine-specific transcription
factor, expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to …

Context.—Differentiation of non–small cell carcinoma into histologic types is important
because of new, successful therapies that target lung adenocarcinoma (ACA). TTF-1 is a …

The expression of 4 thyroid tissue-specific genes [Na+/I− symporter (NIS), thyroid
peroxidase (TPO), thyroglobulin (Tg), TSH receptor (TSH-R)] as well as of the glucose …

Abstract Thyroid transcription factor-1 (TTF-1) is a nuclear homeodomain transcription factor
that is expressed in the developing thyroid, respiratory epithelium, and diencephalon. TTF-1 …

Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in
thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β …

The distinction between small cell lung carcinoma (SCLC) and small cell carcinomas of
other sites is difficult by routine histology. Thyroid transcription factor-1 (TTF-1) is a …

The paired-box (PAX) genes encode a family of nine well-characterized paired-box
transcription factors, with important roles in development and disease. Although PAX genes …

Cell-lineage-specific transcription factors are a group of regulatory proteins expressed in
embryonic, differentiated, or neoplastic cells of the same lineage and represent a valuable …