CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
Effector and memory T-cell differentiation: implications for vaccine development
Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a
programme of proliferation that is closely linked with the acquisition of effector functions and …
programme of proliferation that is closely linked with the acquisition of effector functions and …
[PDF][PDF] The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
A sequence variation (I148M) in patatin‐like phospholipase domain‐containing protein 3
(PNPLA3) is strongly associated with fatty liver disease, but the underlying mechanism …
(PNPLA3) is strongly associated with fatty liver disease, but the underlying mechanism …
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
EJ Wherry, JN Blattman, K Murali-Krishna… - Journal of …, 2003 - Am Soc Microbiol
Chronic viral infections often result in ineffective CD8 T-cell responses due to functional
exhaustion or physical deletion of virus-specific T cells. However, how persisting virus …
exhaustion or physical deletion of virus-specific T cells. However, how persisting virus …
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
Establishing a CD8+ T cell–mediated immune correlate of protection in HIV disease is
crucial to the development of vaccines designed to generate cell-mediated immunity …
crucial to the development of vaccines designed to generate cell-mediated immunity …
Memory CD8 T-cell differentiation during viral infection
Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …
infections, and understanding their development will aid in the design of optimal vaccines …
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
P Kiepiela, K Ngumbela, C Thobakgale, D Ramduth… - Nature medicine, 2007 - nature.com
Selection of T-cell vaccine antigens for chronic persistent viral infections has been largely
empirical. To define the relationship, at the population level, between the specificity of the …
empirical. To define the relationship, at the population level, between the specificity of the …
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity
M Rosás-Umbert, JD Gunst, MH Pahus… - Nature …, 2022 - nature.com
In simian-human immunodeficiency virus (SHIV)-infected non-human primates, broadly
neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To …
neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To …
HIV and HLA class I: an evolving relationship
PJR Goulder, BD Walker - Immunity, 2012 - cell.com
Successful vaccine development for infectious diseases has largely been achieved in
settings where natural immunity to the pathogen results in clearance in at least some …
settings where natural immunity to the pathogen results in clearance in at least some …
High antigen levels are the cause of T cell exhaustion during chronic viral infection
SN Mueller, R Ahmed - Proceedings of the National …, 2009 - National Acad Sciences
Many persistent viral infections induce dysfunctional T cell responses. Although a negative
correlation exists between viral load and T cell responses during chronic infection, it is not …
correlation exists between viral load and T cell responses during chronic infection, it is not …