Alkyl fluorides modulate the conformation, lipophilicity, metabolic stability, and pKa of
compounds containing aliphatic motifs and, therefore, have been valuable for medicinal …

The increasing demand for the development of unprecedented routes to access fluorinated
molecules has led researchers to perform intriguing research around the world. In this …

Twelve new complexes Cu (L1) 2–Cu (L12) 2 were designed and synthesized to improve
their chemotherapeutic properties. They showed considerable antiproliferative activity …

Fluorinated motifs are frequently encountered in drugs and agrochemicals. Incorporating
fluorine-containing motifs in drug candidates for lead optimization in pharmaceutical …

We designed and prepared a novel series of urea derivatives with/without sulfonyl group in
their structures to investigate the impact of the sulfonyl group on the biological activity of the …

A catalytic monofluoroalkylation of terminal and internal olefins is described. This protocol is
distinguished by its mild conditions, wide scope─ including the utilization of chemical …

Emerging as a powerful tool for lead optimization in pharmaceutical research and
development, to develop the facile, general protocols that allows the incorporation of fluorine …

Alcohols are abundant and attractive feedstock molecules for organic synthesis. Many
methods for their functionalization require them to first be converted into a more activated …

The search for new drugs has been greatly accelerated by the emergence of new viruses
and drug-resistant strains of known pathogens. Nucleoside analogues (NAs) are a …

The construction of the SCF3‐containing 1, 1‐diaryl tertiary carbon stereocenters with high
enantioselectivities is reported via a nickel‐catalyzed asymmetric C− C coupling strategy …