The discovery of the first gene associated with hereditary breast cancer, BRCA1, was
anticipated to greatly increase our understanding of both hereditary and sporadic forms of …

Introduction: Heritage is the most important risk factor for breast cancer. About 15–20% of
breast cancer is familial, referring to affected women who have one or more first-or second …

IN Western Europe and the United States approximately 1 in 12 women develop breast
cancer. A small proportion of breast cancer cases, in particular those arising at a young age …

The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage
and mutation analysis in 237 families, each with at least four cases of breast cancer …

Breast cancer is a global burden with a woman's lifetime risk of developing breast cancer at
1 in 8. Although breast cancer is a disease that affects mostly women, the lifetime risk in men …

A small proportion of breast cancer, in particular those cases arising at a young age, is due
to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A …

Men who carry germline mutations in the BRCA2 gene have a higher risk of developing
breast carcinoma than men in the general population. Men who carry germline mutations in …

Objective. To determine if male breast carcinogenesis was similar to its more common
female counterpart, we compared incidence patterns among men and women with breast …

Background Hereditary breast cancer runs in families where several members in different
generations are affected. Most of these breast cancers are caused by mutations in the high …

BACKGROUND The purpose of this investigation was to determine if there are pathobiologic
differences between BRCA1‐related and BRCA2‐related hereditary breast cancer (HBC) …