Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …

We initiated the systematic profiling of the dorsolateral prefrontal cortex obtained from a
subset of autopsied individuals enrolled in the Religious Orders Study (ROS) or the Rush …

Depression is a common condition, but current treatments are only effective in a subset of
individuals. To identify new treatment targets, we integrated depression genome-wide …

We report a multi-omic resource generated by applying quantitative trait locus (xQTL)
analyses to RNA sequence, DNA methylation and histone acetylation data from the …

There is a need for new therapeutic targets with which to prevent Alzheimer's disease (AD),
a major contributor to aging-related cognitive decline. Here we report the construction and …

The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort
study of common chronic conditions of aging with an emphasis on decline in cognitive and …

The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and
Alzheimer's disease (AD). In this manuscript, we summarize the study methods including the …

The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is
genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been …