Background Osteoarthritis is the most common joint disease of adults worldwide. Its
incidence rises with age. Both intrinsic and extrinsic risk factors promote its development. In …

Nonsteroidal anti-inflammatory drugs (NSAIDs), including both traditional nonselective
NSAIDs and the selective cyclooxygenase (COX)-2 inhibitors, are widely used for their anti …

Pain is the defining symptom of osteoarthritis (OA), yet available treatment options, of which
NSAIDs are the most common, provide inadequate pain relief and are associated with …

Objective To estimate the analgesic efficacy of non-steroidal anti-inflammatory drugs
(NSAIDs), including selective cyclo-oxygenase-2 inhibitors (coxibs), in patients with …

Objectives: To provide an updated document assessing the global, NSAID-specific, and time
dependent risk of gastrointestinal (GI) complications through meta-analyses of high quality …

Pain ranges in prevalence from 14–100% among cancer patients and occurs in 50–70% of
those in active treatment. Cancer pain may result from direct invasion of tumor into nerves …

Background A previous systematic review reported that topical NSAIDs were effective in
relieving pain in acute conditions like sprains and strains, with differences between …

Total knee arthroplasty has been extremely successful in elderly patients with osteoarthritis.
However, there is considerable controversy regarding how best to treat the younger, athletic …

Among musculoskeletal diseases, osteoarthritis (OA) is by far the most common form of
arthritis and results in vast morbidity and societal costs. It is estimated that the overall costs …

Introduction Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and
decreased function. OA is treated with a wide range of modalities, both conservatively and …