Natural products are used since ancient times in folklore for the treatment of various
ailments. Plant‐derived products have been recognized for many years as a source of …

In this" Critical Review" we made a historical introduction of drugs assayed against Chagas
disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental …

A rational approach is needed to maximize the chances of finding new drugs, and to exploit
the opportunities of potential new drug targets emerging from genomic and proteomic …

A series of (NHC) Pd (R-allyl) Cl complexes [NHC: IPr= N, N '-bis (2, 6-diisopropylphenyl)
imidazol-2-ylidene, SIPr= N, N '-bis (2, 6-diisopropylphenyl)-4, 5-dihydroimidazol-2-ylidene; …

Recent advances in high-throughput protein structure determination and in computational
chemistry have refocussed attention on virtual screening and fast automated docking …

Can we consider cancer to be a “metabolic disease”? Tumors are the result of a metabolic
selection, forming tissues composed of heterogeneous cells that generally express an …

Shikimic acid properties and its available analytical techniques are discussed. Plants having
the highest content of shikimic acid are shown. The existing isolation methods are analyzed …

Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement
and fatal systemic infection. WHO estimates that the disease results in 2 million new cases a …

Purine salvage is an essential function for all obligate parasitic protozoa studied to date and
most are also capable of efficient uptake of preformed pyrimidines. Much progress has been …

Background: The radio-and chemotherapeutics currently used for the treatment of cancer
are widely known to be characterized by a low therapeutic index. An interesting approach to …