Sex and gender in neurodevelopmental conditions

S Bölte, J Neufeld, PB Marschik, ZJ Williams… - Nature Reviews …, 2023 - nature.com
Health-related conditions often differ qualitatively or quantitatively between individuals of
different birth-assigned sexes and gender identities, and/or with different gendered …

Annual Research Review: Attention‐deficit/hyperactivity disorder in girls and women: underrepresentation, longitudinal processes, and key directions

SP Hinshaw, PT Nguyen, SM O'Grady… - Journal of Child …, 2022 - Wiley Online Library
Attention‐deficit/hyperactivity disorder (ADHD)–and its underlying behavioral dimensions of
inattention and hyperactivity–impulsivity–have been understudied in females. We first cover …

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

D Demontis, GB Walters, G Athanasiadis, R Walters… - Nature …, 2023 - nature.com
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder
with a major genetic component. Here, we present a genome-wide association study meta …

The GTEx Consortium atlas of genetic regulatory effects across human tissues

GTEx Consortium - Science, 2020 - science.org
The Genotype-Tissue Expression (GTEx) project was established to characterize genetic
effects on the transcriptome across human tissues and to link these regulatory mechanisms …

SynGO: an evidence-based, expert-curated knowledge base for the synapse

F Koopmans, P van Nierop, M Andres-Alonso… - Neuron, 2019 - cell.com
Synapses are fundamental information-processing units of the brain, and synaptic
dysregulation is central to many brain disorders (" synaptopathies"). However, systematic …

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

MB Stein, DF Levey, Z Cheng, FR Wendt… - Nature …, 2021 - nature.com
We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …

[HTML][HTML] Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders

PF Sullivan, DH Geschwind - Cell, 2019 - cell.com
Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …

Single nucleus multi-omics identifies human cortical cell regulatory genome diversity

C Luo, H Liu, F Xie, EJ Armand, K Siletti, TE Bakken… - Cell genomics, 2022 - cell.com
Single-cell technologies measure unique cellular signatures but are typically limited to a
single modality. Computational approaches allow the fusion of diverse single-cell data …

Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

A Ganna, KJH Verweij, MG Nivard, R Maier, R Wedow… - Science, 2019 - science.org
INTRODUCTION Across human societies and in both sexes, some 2 to 10% of individuals
report engaging in sex with same-sex partners, either exclusively or in addition to sex with …

[HTML][HTML] Male sex bias in early and late onset neurodevelopmental disorders: Shared aspects and differences in Autism Spectrum Disorder, Attention Deficit …

S Santos, H Ferreira, J Martins, J Gonçalves… - Neuroscience & …, 2022 - Elsevier
Neurodevelopmental disorders are characterized by relatively early onset, with temporal
variations across conditions. These lifelong conditions lead to social and communication …