Embryonic stem cell (ESC) markers are molecules specifically expressed in ES cells.
Understanding of the functions of these markers is critical for characterization and …

Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in
anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly …

Objective To determine the molecular characteristics of human spermatogonia and optimize
methods to enrich spermatogonial stem cells (SSCs). Design Laboratory study using human …

The recent reports on the treatment of azoospermia patients, in which spermatozoa could
not be traced in their testes, are focused more on the potential use of adult stem cells, like …

Abstract The international Testicular Cancer Consortium (TECAC) combined five published
genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and …

Primary mediastinal germ cell tumors (GCTs) are rare and sometimes they pose diagnostic
difficulty without immunohistochemical studies. Here, we investigated the diagnostic utility of …

Historically, spontaneous deletions and insertions have provided means to probe germline
developmental genetics in Drosophila, mouse and other species. Here, induced pluripotent …

Background Testicular dysgenesis syndrome (TDS) is a common disease that links testicular
germ cell cancer, cryptorchidism and some cases of hypospadias and male infertility with …

The transcription factor octamer-binding transforming factor 4 (Oct-4) is central to the gene
regulatory network responsible for self-renewal, pluripotency, and lineage commitment in …

BACKGROUND A key step in studying the biology of spermatogonia is to determine their
global gene expression profile. However, disassociation of these cells from the testis may …