Compressor selection is one of the primary functions in operation of natural gas pipelines,
and a major concern of the task is to minimize operating costs. This study presents a …

We investigate protein purification operations conducted by biomanufacturers and
pharmaceutical companies as part of their research and development efforts. Purification of …

The strategies employed in chromatography steps play a key role in downstream processes
for monoclonal antibody (mAb) manufacture. This work addresses the integrated …

Chromatography operations are identified as critical steps in a monoclonal antibody (mAb)
purification process and can represent a significant proportion of the purification material …

The development of systematic methods for the synthesis of downstream protein processing
operations has seen growing interest in recent years, as purification is often the most …

This paper presents a Mixed-Integer Linear Programming (MILP) model to optimize the
compressor selection operations in natural gas pipeline network system. The objectives of …

Downstream bioprocessing and especially chromatographic steps, commonly used for the
purification of multicomponent systems, are significant cost drivers in the production of …

This work addresses rapid resin selection for integrated chromatographic separations when
conducted as part of a high‐throughput screening exercise during the early stages of …

Novel and efficient linear formulations are developed for the problem of simultaneously
performing an optimal synthesis of chromatographic protein purification processes, and the …

A generic, knowledge‐based guideline assisting downstream process synthesis for
biochemical products is presented. It offers process designers a structured process design …