The continual demand for specialized molecular cloning techniques that suit a broad range
of applications has driven the development of many different cloning strategies. One method …

Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …

Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients,
versatile tools in drug discovery, and for drug delivery. They find themselves at the …

Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's,
are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the …

Mitochondria are complex organelles with different compartments, each harbouring their
own protein quality control factors. While chaperones of the mitochondrial matrix are well …

Structural, biochemical and biophysical studies of eukaryotic soluble and membrane
proteins require their production in milligram quantities. Although large-scale protein …

Gene expression in Arabidopsis is regulated by more than 1,900 transcription factors (TFs),
which have been identified genome-wide by the presence of well-conserved DNA-binding …

G-protein-coupled receptors (GPCRs) are divided phylogenetically into six classes,, denoted
A to F. More than 370 structures of vertebrate GPCRs (belonging to classes A, B, C and F) …

AMPA glutamate receptors (AMPARs), the primary mediators of excitatory
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …

CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of
small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these …