T follicular helper cell biology: a decade of discovery and diseases

S Crotty - Immunity, 2019 - cell.com
Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

Pathophysiology of chronic graft-versus-host disease and therapeutic targets

R Zeiser, BR Blazar - New England Journal of Medicine, 2017 - Mass Medical Soc
Chronic GVHD, an autoimmune disease that follows allogeneic hematopoietic-cell
transplantation, is characterized by infections and debilitating tissue injury leading to …

Ibrutinib for chronic graft-versus-host disease after failure of prior therapy

D Miklos, CS Cutler, M Arora, EK Waller… - Blood, The Journal …, 2017 - ashpublications.org
Chronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic stem cell
transplantation with few effective options available after failure of corticosteroids. B and T …

[HTML][HTML] The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health Consensus Development Project on Criteria for …

KR Cooke, L Luznik, S Sarantopoulos, FT Hakim… - Biology of Blood and …, 2017 - Elsevier
Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey

R Zeiser, A Burchert, C Lengerke, M Verbeek… - Leukemia, 2015 - nature.com
Despite major improvements in allogeneic hematopoietic cell transplantation over the past
decades, corticosteroid-refractory (SR) acute (a) and chronic (c) graft-versus-host disease …

Current concepts and advances in graft-versus-host disease immunology

GR Hill, BC Betts, V Tkachev, LS Kean… - Annual review of …, 2021 - annualreviews.org
Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …

Chronic graft-versus-host disease: biological insights from preclinical and clinical studies

KPA MacDonald, GR Hill… - Blood, The Journal of the …, 2017 - ashpublications.org
With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor–
mobilized peripheral blood stem cell donor grafts and successful treatment of older …

[HTML][HTML] National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-Host disease: IV. the 2020 highly morbid forms …

D Wolff, V Radojcic, R Lafyatis, R Cinar… - … and cellular therapy, 2021 - Elsevier
Chronic graft-versus-host disease (GVHD) can be associated with significant morbidity, in
part because of nonreversible fibrosis, which impacts physical functioning (eye, skin, lung …

New approaches for the treatment of chronic graft-versus-host disease: current status and future directions

NEB Saidu, C Bonini, A Dickinson, M Grce… - Frontiers in …, 2020 - frontiersin.org
Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic
hematopoietic stem cell transplantation that affects various organs leading to a reduced …

Cytokines in graft-versus-host disease

AS Henden, GR Hill - The Journal of Immunology, 2015 - journals.aai.org
Graft-versus-host disease (GVHD) is a complication of allogeneic bone marrow
transplantation whereby transplanted naive and marrow-derived T cells damage recipient …