Counter-regulatory renin–angiotensin system in cardiovascular disease

M Paz Ocaranza, JA Riquelme, L García… - Nature Reviews …, 2020 - nature.com
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

The renin–angiotensin system in cardiovascular autonomic control: recent developments and clinical implications

AJ Miller, AC Arnold - Clinical Autonomic Research, 2019 - Springer
Complex and bidirectional interactions between the renin–angiotensin system (RAS) and
autonomic nervous system have been well established for cardiovascular regulation under …

Role of autonomic reflex arcs in cardiovascular responses to air pollution exposure

CM Perez, MS Hazari, AK Farraj - Cardiovascular toxicology, 2015 - Springer
The body responds to environmental stressors by triggering autonomic reflexes in the
pulmonary receptors, baroreceptors, and chemoreceptors to maintain homeostasis …

Role of NRF2 and Sirtuin activators in COVID-19

H Khan, S Patel, A Majumdar - Clinical Immunology, 2021 - Elsevier
COVID-19 is a pandemic requiring immediate solution for treatment because of its complex
pathophysiology. Exploration of novel targets and thus treatment will be life savers which is …

Theories and molecular basis of vascular aging: a review of the literature from vascagenet group on pathophysiological mechanisms of vascular aging

E Gkaliagkousi, A Lazaridis, S Dogan… - International journal of …, 2022 - mdpi.com
Vascular aging, characterized by structural and functional alterations of the vascular wall, is
a hallmark of aging and is tightly related to the development of cardiovascular mortality and …

Rutin modulates MAPK pathway differently from quercetin in angiotensin II-induced H9c2 cardiomyocyte hypertrophy

HN Siti, J Jalil, AY Asmadi, Y Kamisah - International Journal of Molecular …, 2021 - mdpi.com
Rutin is a flavonoid with antioxidant property. It has been shown to exert cardioprotection
against cardiomyocyte hypertrophy. However, studies regarding its antihypertrophic property …

Relationship between saturated fatty acid intake and hypertension and oxidative stress

H Nakamura, H Tsujiguchi, Y Kambayashi, A Hara… - Nutrition, 2019 - Elsevier
Objectives This study investigated the relationship between saturated fatty acid (SFA) intake
and hypertension and oxidative stress. Methods The present cross-sectional study was …

Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease

RM Lataro, F Brognara, R Iturriaga, JFR Paton - Autonomic Neuroscience, 2024 - Elsevier
The sensitization and hypertonicity of visceral afferents are highly relevant to the
development and progression of cardiovascular and respiratory disease states. In this …

Alteration in brain functional and effective connectivity in subjects with hypertension

L Bu, C Huo, G Xu, Y Liu, Z Li, Y Fan, J Li - Frontiers in physiology, 2018 - frontiersin.org
To reveal the physiological mechanism of the cognitive decline in subjects with
hypertension, the functional connectivity (FC) was assessed by using the wavelet phase …

Potential mechanisms underlying COVID-19-mediated central and peripheral demyelination: Roles of the RAAS and ADAM-17

KB Oliveira, FMA de Souza, LBM de Sá… - Molecular …, 2025 - Springer
Demyelination is among the most conspicuous neurological sequelae of SARS-CoV-2
infection (COVID-19) in both the central (CNS) and peripheral (PNS) nervous systems …