Bioluminescence is the fascinating natural phenomenon by which living creatures produce
light. Bioluminescence occurs when the oxidation of a small-molecule luciferin is catalysed …

Mitochondrial metabolism has emerged as a promising target against the mechanisms of
tumor growth. Herein, we have screened an FDA-approved library to identify drugs that …

The coexistence of two pools of ATP synthase in mitochondria has been largely neglected
despite in vitro indications for the existence of reversible active/inactive state transitions in …

Simple Summary The ATPase Inhibitory Factor 1 (IF1) plays a prominent role as an inhibitor
of mitochondrial ATP synthase. Herein we review the role of IF1 in promoting the Warburg …

The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the
production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor …

The ATPase inhibitory factor 1 (IF1) is an intrinsically disordered protein that regulates the
activity of the mitochondrial ATP synthase. Phosphorylation of S39 in IF1 prevents it from …

Partial suppression of mitochondrial oxidative phosphorylation and the concurrent activation
of aerobic glycolysis is a hallmark of proliferating cancer cells. Overexpression of the …

Results HCT116 and Jurkat cancer cells have a fraction of inactive ATP synthase. HCT116
cells were used for the generation of IF1-knock-out (IF1-KO) cells by CRISPR-Cas9 …