Unfortunately, last year we have witnessed one of the worst global health crises in recent
history. SARS-COV-2 pandemic outbreak has revealed that global healthcare systems were …

Organ on-a-chip (OoC) is a promising technology that aims to recapitulate human body
pathophysiology in a more precise way to advance in drug development and complex …

Background Camptothecin (CPT) is one of the frequently used small chemotherapy drugs for
treating hepatocellular carcinoma (HCC), but its clinical application is limited due to severe …

Macrophages play an essential role in alcohol-induced inflammation and oxidative stress.
We investigated the effects of nicotinamide riboside (NR), a natural nicotinamide adenine …

Dietary supplementation is the most feasible method to improve oocyte function and
developmental potential in vivo. During three experiments, oocytes were collected from …

Mitochondria are the primary sites of oxygen (O 2) consumption and energy metabolism in
most cell types, but also produce reactive oxygen species (ROS) that contribute to a wide …

Recent advances in microfluidic engineering allow the creation of microenvironments in
which human cells can be cultured under (patho-) physiological conditions with greater …

Advanced maternal age is associated with a decline in fertility and oocyte quality. We used
novel metabolic microsensors to assess effects of mare age on single oocyte and embryo …

Obesity is a growing concern in human and equine populations, predisposing to metabolic
pathologies and reproductive disturbances. Cellular lipid accumulation and mitochondrial …

Well plates are widely used in biological experiments, particularly in pharmaceutical
sciences and cell biology. Its popularity stems from its versatility to support a variety of …