Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms
Nitric oxide (NO) is an important vasodilator with a well-established role in cardiovascular
homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and …
homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and …
[HTML][HTML] Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases
Nitric oxide (NO) is a vasoactive substance synthesized from l-arginine by neuronal (NOS1),
endothelial (NOS3), and inducible (NOS2) nitric oxide synthases. NOS3 is the most …
endothelial (NOS3), and inducible (NOS2) nitric oxide synthases. NOS3 is the most …
Polymorphisms in Endothelial Nitric Oxide Synthase (eNOS) and Vascular Endothelial Growth Factor (VEGF) Predict Sunitinib‐Induced Hypertension
K Eechoute, AAM Van Der Veldt… - Clinical …, 2012 - Wiley Online Library
Hypertension is an important side effect of sunitinib treatment. In a retrospective study in 255
patients, single‐nucleotide polymorphisms (SNPs) in vascular endothelial growth factor A …
patients, single‐nucleotide polymorphisms (SNPs) in vascular endothelial growth factor A …
eNOS Haplotypes Associated with Gestational Hypertension or Preeclampsia
Aims: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been
inconsistently associated with preeclampsia. We compared genotype and haplotype …
inconsistently associated with preeclampsia. We compared genotype and haplotype …
Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia
Pre-eclampsia (PE) is associated with decreased nitric oxide (NO) formation. However, no
previous study has examined whether genetic variations in the endothelial NO synthase …
previous study has examined whether genetic variations in the endothelial NO synthase …
eNOS haplotypes affect the responsiveness to antihypertensive therapy in preeclampsia but not in gestational hypertension
Variations of the endothelial nitric oxide synthase (eNOS) gene have been associated with
hypertensive disorders of pregnancy. We examined whether eNOS polymorphisms affect the …
hypertensive disorders of pregnancy. We examined whether eNOS polymorphisms affect the …
Effects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older people
The polymorphisms of endothelial nitric oxide synthase (eNOS) are associated with reduced
eNOS activity. Aerobic exercise training (AEX) may influence resting nitric oxide (NO) …
eNOS activity. Aerobic exercise training (AEX) may influence resting nitric oxide (NO) …
eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril
Purpose The antihypertensive effect of angiotensin-converting enzyme inhibitors (ACEi) is
attributed partially to increased nitric oxide bioavailability. It is possible that functional …
attributed partially to increased nitric oxide bioavailability. It is possible that functional …
NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids
JF Ferguson, CM Phillips, J McMonagle… - Atherosclerosis, 2010 - Elsevier
OBJECTIVE: Omega-3 polyunsaturated fatty acids (n-3 PUFA) may protect against the
development of cardiovascular disease (CVD). Genotype at key genes such as nitric oxide …
development of cardiovascular disease (CVD). Genotype at key genes such as nitric oxide …
Influence of endothelial nitric oxide synthase haplotypes on nitric oxide and peroxynitrite productions
SO Alsulami, T Malinski, HD Dewald - Bioelectrochemistry, 2025 - Elsevier
The impact of four clinically significant genetic variants of endothelial nitric oxide synthase
(eNOS) polymorphisms on the concentrations of nitric oxide [NO] and peroxynitrite [ONOO–] …
(eNOS) polymorphisms on the concentrations of nitric oxide [NO] and peroxynitrite [ONOO–] …