The development of a T cell receptor excision circle (TREC) assay utilizing dried blood spots
(DBS) made possible universal newborn screening (NBS) for severe combined …

Inborn errors of metabolism (IEM) are a phenotypically and genetically heterogeneous
group of disorders caused by a defect in a metabolic pathway, leading to malfunctioning …

Importance The development of artificial intelligence (AI) and other machine diagnostic
systems, also known as software as a medical device, and its recent introduction into clinical …

Background The use of genome-wide (whole genome or exome) sequencing for population-
based newborn screening presents an opportunity to detect and treat or prevent many more …

Artificial Intelligence Medicine: Technical Basis and Clinical Applications presents a
comprehensive overview of the field, ranging from its history and technical foundations, to …

The language of “personalized medicine” and “personal genomics” has now entered the
common lexicon. The idea of personalized medicine is the integration of genomic risk …

Lead (Pb) exposure remains a major concern in the United States (US) and around the
world, even following the removal of Pb from gasoline and other products. Environmental Pb …

Newborn screening has evolved to include an increasingly complex spectrum of diseases,
raising concerns that screening should be optional and require parental consent. Early …

Each year millions of newborns are part of a newborn disease-screening program in which,
after initial screening, the newborn dried blood spot (NDBS) samples can be stored and …

Abstract Background: Michigan's BioTrust for Health, a public health research biobank
comprised of residual dried bloodspot (DBS) cards from newborn screening contains over 4 …