Platelet aggregation, the process by which platelets adhere to each other at sites of vascular
injury, has long been recognized as critical for hemostatic plug formation and thrombosis …

Protein molecules are subjected to potentially denaturing fluid shear forces during
processing and in circulation in the body. These complex molecules, involved in numerous …

Arterial blood flow enhances glycoprotein Ibα (GPIbα) binding to vWF, which initiates platelet
adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von …

Disturbances of blood flow at sites of atherosclerotic plaque rupture are one of the key
pathogenic events promoting platelet activation and arterial thrombus formation. Shear …

One of the major challenges in nanomedicine is to improve nanoparticle cell selectivity and
adhesion efficiency through designing functionalized nanoparticles of controlled sizes …

Abstract von Willebrand factor (VWF) is a large multimeric adhesive glycoprotein with
complex roles in thrombosis and hemostasis. Abnormalities in VWF give rise to a variety of …

The formation of platelet aggregates during blood clotting is modeled on two scales using
ideas motivated by Peskin's immersed boundary method. The microscopic scale models …

Abstract von Willebrand factor (vWF) was first identified as an adhesive glycoprotein
involved in hemostasis by Zimmermann in 1971. Since then, vWF has been shown to play a …

The systems analysis of thrombosis seeks to quantitatively predict blood function in a given
vascular wall and hemodynamic context. Relevant to both venous and arterial thrombosis, a …

This paper describes extending plug-based microfluidics to handling complex biological
fluids such as blood, solving the problem of injecting additional reagents into plugs, and …