Biointerface design for vertical nanoprobes

R Elnathan, MG Barbato, X Guo, A Mariano… - Nature Reviews …, 2022 - nature.com
Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases

V Mittelheisser, V Gensbittel, L Bonati, W Li… - Nature …, 2024 - nature.com
Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Engineering Efficient CAR‐T Cells via Electroactive Nanoinjection

AR Shokouhi, Y Chen, HZ Yoh, J Brenker… - Advanced …, 2023 - Wiley Online Library
Chimeric antigen receptor (CAR)‐T cell therapy has emerged as a promising cell‐based
immunotherapy approach for treating blood disorders and cancers, but genetically …

Modulation of macrophages by in situ ligand bridging

SY Kim, R Thangam, N Kang, H Hong… - Advanced Functional …, 2023 - Wiley Online Library
Extracellular matrix (ECM) proteins containing cell‐attachable Arg‐Gly‐Asp (RGD)
sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen and laminin …

Ligand coupling and decoupling modulates stem cell fate

R Thangam, SY Kim, N Kang, H Hong… - Advanced Functional …, 2023 - Wiley Online Library
In natural microenvironment, various proteins containing adhesive ligands in fibrous and
non‐fibrous structures dynamically couple and decouple to regulate stem cell fate. Herein …

Electroactive nanoinjection platform for intracellular delivery and gene silencing

AR Shokouhi, Y Chen, HZ Yoh, T Murayama… - Journal of …, 2023 - Springer
Background Nanoinjection—the process of intracellular delivery using vertically configured
nanostructures—is a physical route that efficiently negotiates the plasma membrane, with …

Bioinspired materials for immunoengineering of T cells and natural killer cells

S Sasidharan, DM Davis… - Advanced Functional …, 2024 - Wiley Online Library
Immune responses are directed by the complex interactions of different cell types, including
T cells and Natural Killer (NK) cells, with a key type of interaction being the formation of …

Receptor‐Level Proximity and Fastening of Ligands Modulates Stem Cell Differentiation

G Bae, MS Kim, R Thangam, TM Koo… - Advanced Functional …, 2022 - Wiley Online Library
Cellular adhesion is regulated by the binding of 10 nm sized integrin to Arg‐Gly‐Asp (RGD)
ligands present in extracellular matrix proteins. In this study, seed‐mediated growth of gold …

[HTML][HTML] The mechanobiology of NK cells-'Forcing NK to Sense'target cells

DCP Wong, JL Ding - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Natural killer (NK) cells are innate immune lymphocytes that recognize and kill cancer and
infected cells, which makes them unique 'off-the-shelf'candidates for a new generation of …

Selenium Nanoparticles Enhance NK Cell‐Mediated Tumoricidal Activity in Malignant Pleural Effusion via the TrxR1‐IL‐18RAP‐pSTAT3 Pathway

S Liu, N Li, H Lai, L Xu, Y Zeng, X Chen… - Advanced Functional …, 2024 - Wiley Online Library
Malignant pleural effusion (MPE) poses a significant challenge in local treatment, primarily
attributed to its intricate tumor immune microenvironment. The immunosuppression of …