Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Development of testes in the mammalian embryo requires the formation and assembly of
several cell types that allow these organs to achieve their roles in male reproduction and …

Arguably the most defining moment in our lives is fertilization, the point at which we inherit
either an X or a Y chromosome from our father. The profoundly different journeys of male …

The pivotal point of vertebrate sex determination is the development of the gonad into a
testis or ovary, which governs phenotypic sex through the production of hormones. The …

One of the most promising applications of microarrays is the study of changes in gene
expression associated with the growth and development of mammalian tissues. The testis …

Die fortgesetzte Suche nach dem einzelnen ‚geschlechtsdeterminierenden Gen ': SRY als
TDF? 250 Downstream von SRY–weitere Gene, die hierarchisch unterhalb von SRY als an …

Sex-determining region Y (Sry) is the crucial gene that initiates male sex determination in
most mammals. Although several components of the pathway regulating sexual …

Abstract Wnt4‐/‐XX gonads display features normally associated with testis differentiation,
suggesting that WNT4 actively represses elements of the male pathway during ovarian …

During fetal testis development, fetal Leydig cells (FLCs) are found to be originated from
multiple progenitor cells. FLC specification and function are under tight regulation of specific …

Male reproductive tract abnormalities associated with testicular dysgenesis in humans also
occur in male rats exposed gestationally to some phthalate esters. We examined global …