Precise subcellular targeting approaches for organelle-related disorders

G Shim, YS Youn - Advanced Drug Delivery Reviews, 2024 - Elsevier
Pharmacological research has expanded to the nanoscale level with advanced imaging
technologies, enabling the analysis of drug distribution at the cellular organelle level. These …

Tumor microenvironment stimuli-responsive lipid-drug conjugates for cancer treatment

P Husni, C Lim, KT Oh - International Journal of Pharmaceutics, 2023 - Elsevier
Lipid drug conjugates (LDCs) have attracted considerable attention in the fields of drug
delivery and pharmacology due to their ability to target specific cells, increase drug …

Liposomal iron oxide nanoparticles loaded with doxorubicin for combined chemo-photothermal cancer therapy

T Park, R Amatya, KA Min, MC Shin - Pharmaceutics, 2023 - mdpi.com
Iron oxide nanoparticle (IONP) possesses unique advantages over other nanoparticles in
the use of cancer imaging and therapy. Specifically, it has drawn great attention in the …

[HTML][HTML] Electrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs

JS Kim, S Cheon, MR Woo, S Woo, JE Chung… - Asian Journal of …, 2024 - Elsevier
While spray-drying has been widely utilized to improve the bioavailability of poorly water-
soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large …

Laser-responsive erastin-loaded chondroitin sulfate nanomedicine targeting CD44 and system xc− in liver cancer: A non-ferroptotic approach

SY Yoo, HY Kim, DH Kim, WS Shim, SM Lee… - Journal of Controlled …, 2024 - Elsevier
Erastin, a ferroptosis-inducing system xc− inhibitor, faces clinical challenges due to
suboptimal physicochemical and pharmacokinetic properties, as well as relatively low …

Nanocarriers for nutraceutical delivery: A miniaturized revolution in health

RB Sawant, SP Nikam, A Roy, A Kumar… - Nano-Structures & Nano …, 2024 - Elsevier
With the development of nanocarriers, especially in the area of nutraceutical delivery, the
rapidly expanding field of nanotechnology has brought in a new age of health and well …

Development and characterization of pH-responsive nanocarriers for chemo-photothermal combination therapy of acidic tumors

P Husni, Y Shin, H Jeon, ES Lee, YS Youn… - Journal of Controlled …, 2023 - Elsevier
The combination of photothermal therapy and chemotherapy has been considered a
promising strategy for improving the excellent antitumor activities of these treatments. In this …

Effects of PEG-linker chain length of folate-linked liposomal formulations on targeting ability and antitumor activity of encapsulated drug

C Lim, Y Shin, K Kang, P Husni, D Lee… - International Journal …, 2023 - Taylor & Francis
Introduction Ligand-conjugated liposomes are promising for the treatment of specific
receptor-overexpressing cancers. However, previous studies have shown inconsistent …

Tumor extracellular vesicles carrying antitumor (KLAKLAK) 2 peptide and tumor-specific antigens for improved tumor therapy

E Lee, ES Lee - Journal of Pharmaceutical Investigation, 2023 - Springer
Purpose This study aimed to fabricate tumor-originated extracellular vesicles (EVs) targeting
tumors for use in combination with immunotherapy and chemotherapy. Methods The …

Organometallic Phyllosilicate-Gold Nanocomplex: an effective oral delivery system of Methotrexate for enhanced in vivo efficacy against Colorectal Cancer

R Bajracharya, KC Baral, SH Lee… - International Journal of …, 2023 - Taylor & Francis
Purpose Oral administration, although convenient and preferred for treating colorectal
cancer (CRC), faces challenges due to limited CRC-related intestinal positioning and a …