Radical trifluoromethylation - Chemical Society Reviews (RSC Publishing) DOI:10.1039/D1CS00200G
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Fluorine compounds are known for their abundance in more than 20% of pharmaceutical
and agrochemical products mainly due to the enhanced lipophilicity, metabolic stability and …

A mild and operationally simple C (sp3)− H trifluoromethylation method was developed for
unactivated alkanes by utilizing a bench‐stable CuIII complex, bpyCu (CF3) 3, as the …

Covering: 2011 to 2021 Trifluoromethyl (CF3)-modified natural products have attracted
increasing interest due to their magical effect in binding affinity and/or drug metabolism and …

Organocopper (III) species were generally considered as the key intermediates in a variety
of copper-catalyzed cross-coupling reactions, aerobic oxidations, as well as enzyme …

Alkynes are one of the most fundamental and diverse functional groups utilized in organic
synthesis. Over the past few years, the development of efficient synthetic methodologies for …

Copper-catalyzed coupling reactions of alkyl halides are believed to prominently involve
copper (II) species and alkyl radicals as pivotal intermediates, with their exact interaction …

The introduction of trifluoromethyl groups into organic molecules is of paramount importance
in modern synthetic chemistry and medicinal chemistry. While methods for constructing C …

In the last few years, many reagents and protocols have been developed to allow for the
efficient fluorofunctionalization of a diverse set of scaffolds ranging from alkanes, alkenes …

This study reports sequential dehydrogenation and transfer oxygenation of 1, 2-
diarylepoxides by high-valent phenCu (III)(CF3) 3 and DMSO to produce 1, 2-diketones. The …