Tissue fibrosis, including pulmonary fibrosis, hepatic fibrosis, and cardiac fibrosis, is an
important stage in the development of many diseases. It can lead to structural damage and …

Cardiac fibrosis is associated with most cardiac diseases. Fibrosis is an accumulation of
excessive extracellular matrix proteins (ECM) synthesized by cardiac fibroblasts and …

During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different
scales from the molecular level to the tissue level. One central player that contributes to both …

Key point Fibroblasts play a major role in heart physiology. In pathological conditions, they
can lead to cardiac fibrosis when they differentiate into myofibroblasts. This differentiated …

Fibrosis is characterized by the excessive accumulation of extracellular matrix components,
leading to loss of tissue function in affected organs. Although the majority of fibrotic diseases …

Corneal haze brought on by fibrosis due to insult can lead to partial or complete vision loss.
Currently, corneal transplantation is the gold standard for treating severe corneal fibrosis …

Cardiac function is mediated by interactions between the cellular constituents of the heart,
as well as the extracellular matrix. The major cell types of the heart include cardiac …

Abstract Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates a series of
physiological and pathological processes via binding to five S1P receptors (S1PR1-5) …

Metabolites of sphingomyelin, as well as calcium ion fluxes, have a profound role in cellular
signaling in almost all cell types. In addition, metabolites of sphingomyelin often modulate …

Abstract Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite generated
by phosphorylation of sphingosine catalyzed by sphingosine kinase. S1P acts mainly …