Summary The interleukin (IL)‐1 family of cytokines is currently comprised of 11 members
that have pleiotropic functions in inflammation and cancer. IL‐1α and IL‐1β were the first …

Neonates have little immunological memory and a developing immune system, which
increases their vulnerability to infectious agents. Recent advances in the understanding of …

In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy,
in particular, is a time of increased disease susceptibility and severity. Early-life viral …

The human immune system comprises cellular and molecular components designed to
coordinately prevent infection while avoiding potentially harmful inflammation and …

The fetus and newborn face a complex set of immunological demands, including protection
against infection, avoidance of harmful inflammatory immune responses that can lead to pre …

This work describes the nature and strength of the immune response induced by various Toll-
like receptor ligands and their ability to act as vaccine adjuvants. It reviews the various …

During early post-natal life, neonates must adjust to the transition from the sheltered intra-
uterine environment to the microbe-laden external world, wherein they encounter a …

The human neonate and infant are unduly susceptible to infection with a wide variety of
microbes. This susceptibility is thought to reflect differences from adults in innate and …

Abstract Background Neutrophil extracellular traps (NETs) are innate defense mechanisms
that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs …

New Approaches to Preventing, Diagnosing, and Treating Neonatal Sepsis | PLOS Medicine
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