In chronic kidney disease (CKD), progressive nephron loss causes glomerular sclerosis, as
well as tubulointerstitial fibrosis and progressive tubular injury. In this study, we aimed to …

Inhibitors of mammalian target of rapamycin (mTOR) have immunosuppressive and anti-
cancer effects, but their effects on the progression of kidney disease are not fully understood …

Recent studies have revealed the impact of antibiotic-induced microbiome depletion (AIMD)
on host glucose homeostasis. The kidney has a critical role in systemic glucose …

Because of the difficulty in detecting segment-specific response in the kidney, we
investigated the molecular events underlying acute kidney injury in the proximal tubules of …

Background/Aims: Angiotensin (Ang) II contributes to tubulointerstitial fibrosis. Recent data
highlight mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) signaling in …

Chronic kidney disease (CKD) is a highly heterogeneous nephrosis that occurs when the
structure and function of the kidney is damaged. Gene expression studies have been widely …

Riboflavin, also known as vitamin B2, is transported across the biological membrane into
various organs by transport systems. Riboflavin transporter RFVT3 is expressed in the small …

Rapamycin, an immunosuppressant, is widely used in patients with kidney transplant.
However, the therapeutic effects of rapamycin remain controversial. Additionally, previous …

Objective: Diabetic nephropathy is characterized by the accumulation of extracellular matrix
in the glomerular mesangium as a result of an imbalance between matrix synthesis and …

目的观察富含半胱氨酸蛋白61 (Cyr61) 蛋白对人肾小管上皮细胞(HK⁃ 2)
增殖与细胞周期的影响. 方法细胞被分为空白对照, 阴性对照和Cyr61 转染组. 克隆Cyr61 cDNA …