Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …

The synapse is the focus of experimental research and theory on the cellular mechanisms of
nervous system plasticity and learning, but recent research is expanding the consideration …

The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS)
lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes …

Whereas the cerebral cortex has long been regarded by neuroscientists as the major locus
of cognitive function, the white matter of the brain is increasingly recognized as equally …

In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between
demyelination and remyelination can trigger progressive degenerative processes. The …

Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …

Activity-dependent myelination is thought to contribute to adaptive neurological function.
However, the mechanisms by which activity regulates myelination and the extent to which …

It has been well documented that neurotrophins, including brain-derived neurotrophic factor
(BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a …

Activity of the nervous system has long been recognized as a critical modulator of brain
structure and function. Influences of experience on the cytoarchitecture and functional …

Oligodendrocyte precursor cells (OPCs) in the adult brain contribute to white matter
homeostasis. After white matter damage, OPCs compensate for oligodendrocyte loss by …