Cholesterol is a fundamental molecule necessary for the maintenance of cell structure and is
vital to various normal biological functions. It is a key factor in lifestyle-related diseases …

Breast cancer is the most prevalent cancer and primary cause of cancer-related mortality in
women. The identification of risk factors can improve prevention of cancer, and obesity and …

Hypercholesterolemia and dyslipidemia are associated with an increased risk for many
cancer types and with poor outcomes in patients with established disease. Whereas the …

Lipid metabolic reprogramming is involved in mediating tamoxifen (TAM) response in breast
cancer cells. Published microarray data indicated that ATP citrate lyase (ACLY) is …

Obesity and elevated circulating cholesterol are risk factors for breast cancer recurrence,
while the use of statins, cholesterol biosynthesis inhibitors widely used for treating …

Background A number of epidemiological and genetic studies have attempted to determine
whether levels of circulating lipids are associated with risks of various cancers, including …

Tumor eradication may be greatly improved by targeting cancer stem cells (CSCs), as they
exhibit resistance to conventional therapy. To gain insight into the unique biology of CSCs …

Background Tamoxifen treatment of estrogen receptor (ER)-positive breast cancer reduces
mortality by 31%. However, over half of advanced ER-positive breast cancers are …

Background Breast cancer is the second most common cause of cancer-related death
among women. Advances in our understanding of the disease have translated into better …

Metabolic syndrome is a type of multifactorial metabolic disease with the presence of at least
three factors: obesity, diabetes mellitus, low high-density lipoprotein, hypertriglyceridemia …