Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Background Intermediate hyperglycaemia (IH) is characterised by one or more
measurements of elevated blood glucose concentrations, such as impaired fasting glucose …

Concerns that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), the etiological agent of coronavirus disease 2019 (COVID-19), may cause new-onset …

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We
performed a genome-wide association study for whole body (20 cohorts of European …

The Notch pathway is a conserved cell-cell communication pathway that controls cell fate
decisions. Here we sought to determine how Notch pathway activation inhibits the …

Type 2 diabetes (T2D) had long been referred to as the" geneticist's nightmare." Genome-
wide association studies have fully confirmed the polygenic nature of T2D, demonstrating …

Genome-wide association (GWAS) and sequencing studies are providing new insights into
the genetic basis of type 2 diabetes (T2D) and the inter-individual variation in glycemic traits …

Understanding the physiological mechanisms by which common variants predispose to type
2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity …

Earlier cohort studies using conventional regression models have consistently shown an
increased cancer risk among individuals with type 2 diabetes. However, reverse causality …