The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

Peripheral nerve lesions provoke apoptosis in the dorsal horn of the spinal cord. The cause
of cell death, the involvement of neurons, and the relevance for the processing of …

Microglia are important mediators of neuroinflammation, which underlies neuropathic pain.
However, the molecular checkpoints controlling microglial reactivity are not well-understood …

The development of chemotherapy-induced painful peripheral neuropathy is a major dose-
limiting side effect of many chemotherapeutics, including bortezomib, but the mechanisms …

Chronic neuropathic pain is a debilitating condition that remains challenging to treat.
Glutamate N-methyl-d-aspartate receptor (NMDAR) antagonists have been used to treat …

Presynaptic NMDA receptors (preNMDARs) play pivotal roles in excitatory
neurotransmission and synaptic plasticity. They facilitate presynaptic neurotransmitter …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

NMDA receptors in primary afferent terminals can contribute to hyperalgesia by increasing
neurotransmitter release. In rats and mice, we found that the ability of intrathecal NMDA to …

NMDA receptors (NMDARs) are glutamate-gated ion channels widely expressed in the
central nervous system (CNS) and endowed with unique biophysical, pharmacological and …