Regulation of inflammation by the antioxidant haem oxygenase 1

NK Campbell, HK Fitzgerald, A Dunne - Nature Reviews Immunology, 2021 - nature.com
Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

The diverse roles of heme oxygenase-1 in tumor progression

KN Luu Hoang, JE Anstee, JN Arnold - Frontiers in immunology, 2021 - frontiersin.org
Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in
response to a variety of stimuli to degrade heme, which generates the biologically active …

Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation

SW Ryter, AMK Choi - Translational Research, 2016 - Elsevier
The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

A Paine, B Eiz-Vesper, R Blasczyk… - Biochemical …, 2010 - Elsevier
Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of
heme degradation. Induction of HO-1 protects against the cytotoxicity of oxidative stress and …

How tolerogenic dendritic cells induce regulatory T cells

RA Maldonado, UH von Andrian - Advances in immunology, 2010 - Elsevier
Since their discovery by Steinman and Cohn in 1973, dendritic cells (DCs) have become
increasingly recognized for their crucial role as regulators of innate and adaptive immunity …

Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases

SC Funes, M Rios, A Fernández-Fierro… - Frontiers in …, 2020 - frontiersin.org
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group
degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which …

Carbon monoxide-releasing micelles for immunotherapy

U Hasegawa, AJ Van Der Vlies, E Simeoni… - Journal of the …, 2010 - ACS Publications
With the discovery of important biological roles of carbon monoxide (CO), the use of this gas
as a therapeutic agent has attracted attention. However, the medical application of this gas …

Mechanisms of immune modulation by mesenchymal stromal cells and clinical translation

J Stagg, J Galipeau - Current molecular medicine, 2013 - ingentaconnect.com
Cell therapy with mesenchymal stromal cells (MSCs) is the focus of intensive investigation.
Several clinical trials, including large-scale placebo-controlled phase III clinical trials, are …

Visible-light activatable organic CO-releasing molecules (PhotoCORMs) that simultaneously generate fluorophores

P Peng, C Wang, Z Shi, VK Johns, L Ma… - Organic & …, 2013 - pubs.rsc.org
Novel organic photoCORMs based on micelle-encapsulated unsaturated cyclic α-diketones
were designed and synthesized. These photoCORMs can be activated by visible light, have …

[HTML][HTML] Modulation of antiviral immunity by heme oxygenase-1

JA Espinoza, PA González, AM Kalergis - The American journal of …, 2017 - Elsevier
Heme oxygenase-1 (HO-1) is a stress-inducible, anti-inflammatory, and cytoprotective
enzyme expressed in most cell types in the organism. Under several stress stimuli, HO-1 …