Human cytosolic glutathione transferases: structure, function, and drug discovery

B Wu, D Dong - Trends in pharmacological sciences, 2012 - cell.com
Glutathione transferases (GSTs) are important detoxifying enzymes that catalyze the
conjugation of electrophilic substrates to glutathione. In recent years, GSTs have been of …

A moderately high level of dietary lipid inhibited the protein secretion function of liver in juvenile tiger puffer Takifugu rubripes

H Xu, Z Liao, Q Zhang, Y Wei, M Liang - Aquaculture, 2019 - Elsevier
Tiger puffer have a unique lipid storage pattern. They store lipid predominantly in liver. To
investigate the hepatic physiology of tiger puffer in response to a moderately high level of …

Insights into mechanisms and severity of drug-induced liver injury via computational systems toxicology approach

Y Peng, Z Wu, H Yang, Y Cai, G Liu, W Li, Y Tang - Toxicology Letters, 2019 - Elsevier
Liver is the central place for drug metabolism. Drug-induced liver injury (DILI) is hence
inevitable, and has become one of the leading causes for drug failure in development and …

Comparison of topological clustering within protein networks using edge metrics that evaluate full sequence, full structure, and active site microenvironment similarity

JB Leuthaeuser, ST Knutson, K Kumar… - Protein …, 2015 - Wiley Online Library
The development of accurate protein function annotation methods has emerged as a major
unsolved biological problem. Protein similarity networks, one approach to function …

[图书][B] Protein Structure and Modeling

N Kurochkina - 2019 - Springer
Structure of proteins, nucleic acids, polysaccharides, and lipids is very important for our
understanding of biological processes and life functions. Biological macromolecules are …

Using genomic and proteomic information to characterize the evolution of genes involved in development and adaptation in vertebrates under differential conditions of …

I Khan - 2014 - search.proquest.com
Using genomic and proteomic information to characterize the evolution of genes involved in
development and adaptation in vertebr Page 1 Using genomic and proteomic information to …

[PDF][PDF] STER1, a Novel Receptor-like Kinase: Functions in MAMP Signalling in Arabidopsis

N Dinischiotu - 2010 - core.ac.uk
ABSTRACT S. epidermidis has long been recognized as an important opportunistic
pathogen accounting for the majority of nosocomial infections alongside S. aureus …

[PDF][PDF] Structural studies on enzymes of Biotechnological and Biomedical interest

P Dhavala - 2011 - utupub.fi
Structural studies of proteins aim at elucidating the atomic details of molecular interactions in
biological processes of living organisms. These studies are particularly important in …

Development and optimization of a clustering process that utilizes active site features to identify functionally relevant groups within protein superfamilies

JB Leuthaeuser - 2015 - search.proquest.com
The elucidation of protein molecular function lags far behind the rate of high-throughput
sequencing technology; thus, the development of accurate and efficient computational …

[图书][B] The N-Subdomain of the Thioredoxin Fold of Glutathione Transferase Is Stabilised by Topologically Conserved Leucine Residues

TN Khoza - 2012 - search.proquest.com
The thioredoxin-like (Trx-like) fold is preserved in various protein families with diverse
functions despite their low sequence identity. Glutathione transferases (GSTs) are …