Malignant cells are part of a complex network within the tumor microenvironment, where
their interaction with host cells and soluble mediators, including complement components, is …

The elimination of cancer cells critically depends on the immune system. However, cancers
have evolved a variety of defense mechanisms to evade immune monitoring, leading to …

GT103 is a first-in-class, fully human, IgG3 monoclonal antibody targeting complement factor
H that kills tumor cells and promotes anti-cancer immunity in preclinical models. We …

Tumor-targeting Abs can be used to initiate an antitumor immune program, which appears
essential to achieve a long-term durable clinical response to cancer. We previously …

The complement system plays an integral role in both innate and adaptive immune
responses. Beyond its protective function against infections, complement is also known to …

The complement system, a key component of innate immunity, is involved in seemingly
contradictory aspects of tumor progression and cancer therapy. It can act as an immune …

Cancer remains a formidable global health challenge requiring the continued exploration of
innovative therapeutic approaches. While traditional treatment strategies including surgery …

Angiogenesis, the process of formation of new capillaries from existing blood vessels, is
required for multiple physiological and pathological processes. Complement factor H (CFH) …

The complement system is an immune surveillance system activated by recognizing
structures lacking complement regulators. It is also triggered by pathogen associated …

Tumor targeting antibodies can be used to initiate an antitumor immune program, which
appears essential to achieve a long-term durable clinical response to cancer. We previously …